1626481-98-8

1626394-43-1

The general procedure for the synthesis of ethyl (2S,3S)-3-aminodicyclo[2.2.2]octane-2-carboxylate hydrochloride from the compound (CAS:1626481-98-8) is as follows: free amino esters (including (-)-1, (+)-1, (-)-2 or (+)-2, 98 mg, 5 mmol) were dissolved in anhydrous ethanol (EtOH, 100 mL ) to prepare a 0.05 M solution. Subsequently, the solution was subjected to a hydrogenation reaction in a ThalesNano H-cube TM system using 10% Pd/C as a catalyst, setting a flow rate of 1 mL/min, a reaction temperature of 50 °C, and a hydrogen pressure of 50 bar.After completion of the reaction, the ethanol was removed under vacuum. The residue was dissolved in ethanol containing 22% HCl (2 mL) and stirred for 10 min at room temperature. Finally, the target product amino ester hydrochloride was obtained by removing the solvent.