| Identification | Back Directory | [Name]
teixobactin | [CAS]
1613225-53-8 | [Synonyms]
teixobactin
L-Isoleucine, N-methyl-D-phenylalanyl-L-isoleucyl-L-seryl-D-glutaminyl-D-alloisoleucyl-L-isoleucyl-L-seryl-D-threonyl-L-alanyl-3-[(5S)-2-amino-4,5-dihydro-1H-imidazol-5-yl]-L-alanyl-, (11→8)-lactone | [Molecular Formula]
C58H95N15O15 | [MDL Number]
MFCD32899000 | [MOL File]
1613225-53-8.mol | [Molecular Weight]
1242.47 |
| Hazard Information | Back Directory | [Uses]
Teixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III[1][2][3]. | [Definition]
ChEBI: Teixobactin is a cyclodepsipeptide that is isolated from the previously unculturable bacterial species Eleftheria terrae and is active against gram-positive bacteria. It has a role as an antibacterial agent. It is a peptide antibiotic, a cyclodepsipeptide and a macrocycle. | [in vivo]
Teixobactin (1-20 mg/kg; i.v.; once) shows antibacterial activity in mice[3]. | Animal Model: | Female CD-1 mice (MRSA ATCC33591)[3] | | Dosage: | 1, 2.5, 5, 10, 20 mg/kg | | Administration: | i.v.; once; one hour post-infection | | Result: | Showed good antibacterial activity and all treated animals survived. |
| [References]
[1] Piddock LJ. Teixobactin, the first of a new class of antibiotics discovered by iChip technology? J Antimicrob Chemother. 2015 Oct;70(10):2679-80. DOI:10.1093/jac/dkv175
[2] Parmar A, et al. Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding. Chem Sci. 2017 Dec 1;8(12):8183-8192. DOI:10.1039/c7sc03241b
[3] Ling LL, et al. A new antibiotic kills pathogens without detectable resistance. Nature. 2015 Jan 22;517(7535):455-9. DOI:10.1038/nature14098 |
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