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ChemicalBook--->CAS DataBase List--->1596348-32-1

1596348-32-1

1596348-32-1 Structure

1596348-32-1 Structure
IdentificationBack Directory
[Name]

ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate
[CAS]

1596348-32-1
[Synonyms]

159142
KDOAM 21
KDM5 inhibitor C70
ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate
[Molecular Formula]

C17H28N4O3
[MDL Number]

MFCD30721931
[MOL File]

1596348-32-1.mol
[Molecular Weight]

336.429
Chemical PropertiesBack Directory
[Boiling point ]

466.6±45.0 °C(Predicted)
[density ]

1.099±0.06 g/cm3(Predicted)
[storage temp. ]

-10 to -25°C
[solubility ]

Chloroform: soluble; DMSO: soluble; Ethanol: soluble
[form ]

Liquid
[pka]

8.39±0.28(Predicted)
[color ]

Light yellow to yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS02,GHS07
[Signal word ]

Danger
[Hazard statements ]

H225-H319
[Precautionary statements ]

P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501
Hazard InformationBack Directory
[Uses]

KDOAM 21 is an inhibitor to KDM5A (Lysine Demethylase 5A) which is a protein coding gene.
[Biological Activity]

KDM5-C70 (KDOAM-21) corresponds to the ethyl ester precursor of a selective αKG-competitive KDM5 histone demethylase inhibitor KDM5-C49 (KDOAM-21; KDM5A/B/C/D Ki = 2/1/6.1/3.4 nM vs. KDM4C/6B/3A/2A Ki = 0.51/4.55/2.59/4.4 μM; KDM5A/B/C/D IC50 = 1.1/0.8/3.2/2.7 μM by FDH assay with [αKG] = 1 mM & [E]/[S] = 0.5/15 μM; KDM5A/B/C IC50 = 25/30/59 nM by alphaLISA with [αKG] = 25 μM & [E]/[S] = 10/100 nM). KDM5-C70 treatment selectively upregulates cellular histone H3 trimethylation on Lys4 (H3K4me3)but not on Lys9/7/36 (5 μM3d)and inhibits KDM5-dependent cancer growth (by 85%/MCF7/11d97%/BT474/24dand 70%/ZR-75-1/24d; 5 μM).
[IC 50]

KDM5
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