| Identification | Back Directory | [Name]
(+)-Cloprostenol isopropyl ester | [CAS]
157283-66-4 | [Synonyms]
CPG 6112-95
ISOPROPYL CLOPROSTENAT
Isopropyl Cloprostenate
D-cloprostenol isopropyl ester
(+)-Cloprostenol isopropyl ester
5-Heptenoic acid,7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-butenyl]-3,5-dihydroxycyclopentyl]-, 1-methylethyl ester, (5Z)-
5-Heptenoic acid, 7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-, 1-methylethyl ester, (5Z)- | [Molecular Formula]
C25H35ClO6 | [MDL Number]
MFCD30721580 | [MOL File]
157283-66-4.mol | [Molecular Weight]
466.99 |
| Chemical Properties | Back Directory | [Boiling point ]
600.0±55.0 °C(Predicted) | [density ]
1.227±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer, Under inert atmosphere | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Oil | [pka]
13.41±0.20(Predicted) | [color ]
Colourless |
| Hazard Information | Back Directory | [Description]
(+)-Cloprostenol is a synthetic analog of prostaglandin F2α (PGF2α). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. (+)-Cloprostenol is the optically active, 15(R) enantiomer of cloprostenol responsible for the majority of its biological activity. It is 200 times more potent than PGF2α in terminating pregnancy when given subcutaneously at a daily dose of 0.125 μg/kg in rats and hamsters, without the side effects associated with PGF2α.1 (+)-Cloprostenol was also shown to be a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 value of 3 x 10-12 M.2 (+)-Cloprostenol isopropyl ester is a more lipid soluble form of cloprostenol. | [Uses]
Isopropyl Cloprostenate is an isopropyl ester derivative of Cloprostenol (C587300); an aryl-oxymethyl analog of prostaglandin F2α. | [in vivo]
Cloprostenol isopropyl ester (25 μg/kg; i.p.; daily, for 4 weeks; male mice) induces changes in the evolution of the spermatogenesis and spermiogenesis[1].
Cloprostenol isopropyl ester (1 μg, 30 μL; injected into the eye; for 2, 4 and 6 h) causes pupil constriction in the cat. Cloprostenol isopropyl ester has an efficacious ocular hypotensive in the lasered monkey[2]. | Animal Model: | Male mice (50–80 days)[1] | | Dosage: | 25 μg/kg | | Administration: | Intraperitoneal injection; daily, for 4 weeks | | Result: | Stimulated the androgen synthesis in a time-dependent manner. |
| [IC 50]
FP |
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