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ChemicalBook--->CAS DataBase List--->1564249-38-2

1564249-38-2

1564249-38-2 Structure

1564249-38-2 Structure
IdentificationBack Directory
[Name]

BJE6-106 (B106)
[CAS]

1564249-38-2
[Synonyms]

B106
BJE6-106 (B106)
[Molecular Formula]

C26H23NO2
[MDL Number]

MFCD32197190
[MOL File]

1564249-38-2.mol
[Molecular Weight]

381.47
Chemical PropertiesBack Directory
[Boiling point ]

548.1±50.0 °C(Predicted)
[density ]

1.16±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO:50.0(Max Conc. mg/mL);131.07(Max Conc. mM)
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Biological Activity]

BJE6-106 (B106) is a potent and selective PKCδ inhibitor with IC50 value of 0.05 μM, BJE6-106 (B106) targets PKCδ 1000-fold more selective than the PKC isoenzyme PKCα (IC50=50 μM) . BJE6-106 (B106) induces apoptosis in caspase-dependent cells. BJE6-106 (B106) has tumor-specific effects.
[in vitro]

BJE6-106 (B106) (0.2 μM, 0.5 μM; 24-72 hours) suppresses cell survival in melanoma cell lines with NRAS mutations. BJE6-106 (B106) (0.2 μM, 0.5 μM; 6- 24 hours) triggers caspase-dependent apoptosis, increases the activity of caspase 3/7, the effect of B106 is greater than rottlerin (10-fold) in SBcl2 cells. BJE6-106 (B106) (0.5 μM; 2-10 hours) activates the MKK4-JNK-H2AX Pathway by inducing MKK4, JNK and H2AX activation at different times in SBcl2 cells.

Cell Viability Assay

Cell Line: Melanoma cell lines with NRAS mutations: SBcl2, FM6, SKMEL2, WM1366, WM1361A, and WM852 cells
Concentration: 0.2 μM, 0.5 μM
Incubation Time: 24 hours, 48 hours, or 72 hours
Result: Inhibited cell survival in melanoma cell lines.

Apoptosis Analysis

< td class="col2"> SBcl2 cells
Cell Line:
Concentration: 0.2 μM, 0.5 μM
Incubation Time: 6 hours, 12 hours, or 24 hours
Result: Induced caspase 3/7 activation.

Western Blot Analysis

< /tr> Result:
Cell Line : SBcl2 cells
Concentration: 0.2 μM , 0.5 μM
Incubation Time: 2 hours, 5 hours, 10 hours
Increased phosphorylation of MKK4, JNK and H2AX.
[target]

PKCδ

0.05 μM (IC 50 )

PKCα

50 μM (IC 50 )

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