| Identification | Back Directory | [Name]
HYDROXYFASUDIL MONOHYDROCHLORIDE | [CAS]
155558-32-0 | [Synonyms]
Fasudil Hydroxy
Hydroxyfasudil HCl
Fasudil Impurity 7 HCl
Hydroxyfasudil (HA-1100)
Hydroxyfasudil (HA-1100) HCl
Hydroxyfasudil Hydrochloride
HYDROXYFASUDIL MONOHYDROCHLORIDE
Hydroxyfasudil hydrochloride hydrate
Hydroxyfasudil - CAS 155558-32-0 - Calbiochem
5-(1,4-diazepan-1-ylsulfonyl)-2h-isoquinolin-1-one
Hydroxyfasudil hydrochloride (HA-1100 hydrochloride)
5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol hydrochloride
HA-1100 HYDROCHLORIDE;HA 1100 HYDROCHLORIDE;HA1100 HYDROCHLORIDE
5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone
5-[(1,4-Diazepan-1-yl)sulfonyl]isoquinolin-1(2H)-one Hydrochloride
1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine monohydrochloride
1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate
1(2H)-Isoquinolinone, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1)
Hydroxyfasudil hydrochloride hydrate,1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate | [Molecular Formula]
C14H18ClN3O3S | [MDL Number]
MFCD06411567 | [MOL File]
155558-32-0.mol | [Molecular Weight]
343.829 |
| Chemical Properties | Back Directory | [Melting point ]
>250 (dec.) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
H2O: >5mg/mL | [form ]
solid | [color ]
white | [Water Solubility ]
Soluble in water (20mM) | [InChIKey]
XWWFOUVDVJGNNG-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
A metabolite of Fasudil. A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties. Reported to inhibit the Rho kinase-mediated ( ROCK) contraction both in vitro and in vivo. A | [General Description]
A cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC50 = 0.9 and 1.8 μM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKβ, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo. | [Biochem/physiol Actions]
Cell permeable: yes | [storage]
Store at -20°C |
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