| Identification | Back Directory | [Name]
methyl brevifolincarboxylate | [CAS]
154702-76-8 | [Synonyms]
methyl brevifolincarboxylate
methyl brevifolincarboxylate USP/EP/BP
methyl 7,8,9-trihydroxy-3,5-dioxo-1,2-dihydrocyclopenta[c]isochromene-1-carboxylate
Cyclopenta[c][2]benzopyran-1-carboxylic acid, 1,2,3,5-tetrahydro-7,8,9-trihydroxy-3,5-dioxo-, methyl ester | [Molecular Formula]
C14H10O8 | [MOL File]
154702-76-8.mol | [Molecular Weight]
306.22 |
| Hazard Information | Back Directory | [Uses]
Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate has anti-oxidant activity. Methyl brevifolincarboxylate also inhibits platelet aggregation, lipid metabolism and inflammation[1][2][4][5][6]. | [Definition]
ChEBI: An organic heterotricyclic compound that is 1,2,3,5-tetrahydrocyclopenta[c]isochromene substituted by hydroxy groups at positions 7, 8 and 9, oxo groups at positions 3 and 5 and a methoxycarbonyl group at position 1. Isolated from Phyll
nthus urinaria and Phyllanthus niruri, it exhibits vasorelaxant activity. | [storage]
Store at -20°C | [References]
[1] Wu QY, et al. Chromatographic fingerprint and the simultaneous determination of five bioactive components of geranium carolinianum L. water extract by high performance liquid chromatography. Int J Mol Sci. 2011;12(12):8740-8749. DOI:10.3390/ijms12128740
[2] Fang SH, et al. Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria. J Ethnopharmacol. 2008;116(2):333-340. DOI:10.1016/j.jep.2007.11.040
[3] Iizuka T, et al. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biol Pharm Bull. 2006 Jan;29(1):177-9. DOI:10.1248/bpb.29.177
[4] Iizuka T, et al. Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation. Biol Pharm Bull. 2007 Feb;30(2):382-4. DOI:10.1248/bpb.30.382 |
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