| Identification | Back Directory | [Name]
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC | [CAS]
154436-48-3 | [Synonyms]
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC | [Molecular Formula]
C46H84NO10P | [MOL File]
154436-48-3.mol | [Molecular Weight]
842.15 |
| Hazard Information | Back Directory | [Description]
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC (SAPC; ) by 15-lipoxygenase (15-LO).1 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is toxic to human umbilical vein endothelial cells (HUVECs) when used at a concentration of 100 μM.2 | [Uses]
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC (15(S)-HpETE-SAPC) is a compound studied for the cytotoxicity of phosphatidylcholine hydroperoxides. Its cytotoxicity is exerted through the decomposition of hydroperoxides to produce toxic compounds. | [storage]
Store at -20°C | [References]
1. Morgan, A.H., Hammond, V.J., Morgan, L., et al. Quantitative assays for esterified oxylipins generated by immune cells Nat. Protoc. 5(12),1919-1931(2010).
2. Kaneko, T., Baba, N., and Matsuo, M. Cytotoxicity of phosphatidylcholine hydroperoxides is exerted through decomposition of fatty acid hydroperoxide moiety Curr. Opin. Struct. Biol. 21(2),173-179(1996). |
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