| Identification | Back Directory | [Name]
Biotin-sar-oh | [CAS]
154024-76-7 | [Synonyms]
Biotin-sar-oh
CAS_154024-76-7
Biotin Impurity 68
(+)-Biotin-sarcosine
Glycine,N-[5-(hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl]-N-methyl-, [3aS-(3aa,4b,6aa)]-
2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoyl-methylamino]acetic acid
Glycine, N-[5-(hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl]-N-methyl-, [3aS-(3aα,4β,6aα)]- (9CI) | [Molecular Formula]
C13H21N3O4S | [MDL Number]
MFCD11113162 | [MOL File]
154024-76-7.mol | [Molecular Weight]
315.39 |
| Hazard Information | Back Directory | [Uses]
Biotin-sar-oh is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [Biological Activity]
Biotin-sar-oh is a cleavable ADC linker that can be used to synthesize antibody-drug conjugates (ADCs). | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [target]
| [IC 50]
Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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