| Identification | Back Directory | [Name]
3,5-DICHLORO-4-PYRIDINECARBONITRILE | [CAS]
153463-65-1 | [Synonyms]
4-Cyano-3,5-dichloropyridine
3,5-DICHLOROISONICOTINONITRILE
3,5-DICHLORO-4-PYRIDINECARBONITRILE
3,5-dichloropyridine-4-carbonitrile
4-Pyridinecarbonitrile, 3,5-dichloro-
3,5-Dichloro-4-pyridinecarbonitrile 97+%
3,5-Dichloro-4-pyridinecarbonitrile
3,5-DICHLORO-4-PYRIDINECARBONITRILE ISO 9001：2015 REACH | [Molecular Formula]
C6H2Cl2N2 | [MDL Number]
MFCD00104651 | [MOL File]
153463-65-1.mol | [Molecular Weight]
173 |
| Chemical Properties | Back Directory | [Melting point ]
115-119 °C (lit.) | [Boiling point ]
266.2±35.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
solid | [pka]
-0.84±0.10(Predicted) | [Appearance]
White to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
Example 22A: 3,5-Dichloro-4-pyridinecarboxaldehyde (10.0 g, 57.1 mmol) was mixed with hydroxylamine hydrochloride (5.25 g, 76 mmol), formic acid (50 mL) and sodium bisulfate (5 drops). The mixture was refluxed for 6 hours under nitrogen protection. Upon completion of the reaction, the solvent was removed by vacuum concentration. The resulting solid was dissolved in ether (250 mL), washed sequentially with sodium bicarbonate solution and brine, and the organic phase was dried with magnesium sulfate. After filtration, the organic phase was concentrated and finally recrystallized from hexane to give 8.2 g of the target product, 3,5-dichloroisonicotinonitrile, in 83% yield with a melting point of 114 °C. | [References]
[1] Patent: EP1270577, 2003, A1
[2] Journal of Medicinal Chemistry, 2005, vol. 48, # 23, p. 7374 - 7388
[3] Patent: WO2006/81072, 2006, A1. Location in patent: Page/Page column 17; 37
[4] Heterocycles, 1995, vol. 41, # 4, p. 675 - 688
[5] Patent: US6232320, 2001, B1 |
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