| Identification | Back Directory | [Name]
DFB | [CAS]
15332-10-2 | [Synonyms]
DFB
3,3'-DIFLUOROBENZALDAZINE
[(3-FLUOROPHENYL)METHYLENE]HYDRAZONE-3-FLUOROBENZALDEHYDE
Benzaldehyde, 3-fluoro-, 2-[(3-fluorophenyl)methylene]hydrazone
1-(3-fluorophenyl)-N-[(Z)-(3-fluorophenyl)methylideneamino]methanimine | [Molecular Formula]
C14H10F2N2 | [MDL Number]
MFCD03653615 | [MOL File]
15332-10-2.mol | [Molecular Weight]
244.24 |
| Chemical Properties | Back Directory | [Boiling point ]
326.6±42.0 °C(Predicted) | [density ]
1.12±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
DMSO: ~12 mg/mL
| [form ]
solid
| [pka]
5.78±0.50(Predicted) | [color ]
yellow
|
| Hazard Information | Back Directory | [Uses]
DFB is an allosteric potentiator of mGluR-5. | [Definition]
ChEBI: Bis(3-fluorobenzylidene)hydrazine is an azine and a member of monofluorobenzenes. | [Biological Activity]
Novel allosteric potentiator of the metabotropic glutamate receptor mGlu 5 . Devoid of agonist activity itself, but potentiates (3-6-fold) the action of agonists at mGlu 5 without any effect at other mGlu subtypes (EC 50 for potentiation = 2-5.3 μ M). | [in vivo]
3,3'-Difluorobenzaldazine (40-100 nmol; icv) attenuates the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine[2]. | Animal Model: | Male NMRI and ICR mice (8-9 weeks, 33-40 g)[2] | | Dosage: | 40-100 nmol (~9.7-24.4 μg) | | Administration: | ICV | | Result: | Attenuated the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine.
|
| [storage]
Store at -20°C |
|
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Energy Chemical
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