Identification | Back Directory | [Name]
2-chloro-4-hydroxy-3-(1-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-5-phenylthieno[2,3-b]pyridin-6(7H)-one(WXG01628) | [CAS]
1523493-53-9 | [Synonyms]
PXL770 2-chloro-4-hydroxy-3-(1-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-5-phenylthieno[2,3-b]pyridin-6(7H)-one Thieno[2,3-b]pyridin-6(7H)-one, 2-chloro-4-hydroxy-5-phenyl-3-(5,6,7,8-tetrahydro-1-hydroxy-2-naphthalenyl)- 2-chloro-4-hydroxy-3-(1-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl)-5-phenylthieno[2,3-b]pyridin-6(7H)-one(WXG01628) | [Molecular Formula]
C23H18ClNO3S | [MOL File]
1523493-53-9.mol | [Molecular Weight]
423.91 |
Chemical Properties | Back Directory | [Boiling point ]
629.5±55.0 °C(Predicted) | [density ]
1.455±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.50±1.00(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C23H18ClNO3S/c24-21-17(15-11-10-12-6-4-5-9-14(12)19(15)26)18-20(27)16(13-7-2-1-3-8-13)22(28)25-23(18)29-21/h1-3,7-8,10-11,26H,4-6,9H2,(H2,25,27,28) | [InChIKey]
KPNBBJGVCJQHBR-UHFFFAOYSA-N | [SMILES]
C12SC(Cl)=C(C3=CC=C4C(=C3O)CCCC4)C=1C(O)=C(C1=CC=CC=C1)C(=O)N2 |
Hazard Information | Back Directory | [Uses]
PXL770 is a direct AMP kinase activator. PXL770 can be used in the research of non-alcoholic fatty liver disease (NAFLD)[1]. | [References]
[1] Kenneth Cusi, et al. Efficacy and safety of PXL770, a direct AMP kinase activator, for the treatment of non-alcoholic fatty liver disease (STAMP-NAFLD): a randomised, double-blind, placebo-controlled, phase 2a study. Lancet Gastroenterol Hepatol. 2021, 6, 11. DOI:10.1016/S2468-1253(21)00300-9 |
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