| Identification | Back Directory | [Name]
(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one | [CAS]
1523404-29-6 | [Synonyms]
129208
Vps34-IN-2
Vps34 inhibitor 2
Vps-34-IN-2,Vps34 IN 2,Vps34IN2
(S)-1-(3-Methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyri
(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one
(S)-9-(3-Methyl-2-oxobutyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one
(8S)-6,7,8,9-Tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one
4H-Pyrimido[1,2-a]pyrimidin-4-one, 6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-, (8S)- | [Molecular Formula]
C18H25F3N4O3 | [MDL Number]
MFCD28411355 | [MOL File]
1523404-29-6.mol | [Molecular Weight]
402.41 |
| Chemical Properties | Back Directory | [Boiling point ]
466.4±55.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Ethanol: 50 mg/mL (124.25 mM) | [form ]
Solid | [pka]
0.08±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(8S)-6,7,8,9-Tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one, is a novel, potent and selective inhibitor of Vps34 with IC50s of 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively. | [in vivo]
After administration by the intravenous (iv) route, Vps34-IN-2 (Compound 31) concentrations are quantifiable up to 6, 8, and 24 h (last sampling time) depending on animals. After oral administration (po), Vps34-IN-2 is rapidly absorbed with maximal plasma concentrations observed at 0.5 h and a bioavailability of 85%. Slight rebounds of concentrations are observed at 4 and 8 h after oral dosing with no obvious explanation. After iv injection of Vps34-IN-2 at 3 mg/kg, plasma clearance is found moderate (i.e., 2.3 L/h/kg), corresponding to 44% of hepatic blood flow in this species, volume of distribution at steady state is moderate, and terminal elimination half-life is short[1]. | [IC 50]
Vps34: 2 nM (IC50); SARS-CoV-2: 3.1 μM (IC50); HCoV-229E: 0.7 μM (IC50) |
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