| Identification | Back Directory | [Name]
8-BROMO-CADP-RIBOSE | [CAS]
151898-26-9 | [Synonyms]
Br-cADPR
8-BR-CADPR
BR-CADP-RIBOSE
8-BROMO-CADP-RIBOSE
8-bromo-Cyclic ADP-Ribose
Br-cADP-ribose, Br-cADPR
8-Bromo-cADP-Ribose (8-Br-cADPR)
8-BROMO-CYCLIC ADENOSINE DIPHOSPHATE RIBOSE
8-Bromocyclic adenosine diphosphate ribose sodium salt | [Molecular Formula]
C15H20BrN5O13P2 | [MDL Number]
MFCD00274402 | [MOL File]
151898-26-9.mol | [Molecular Weight]
620.2 |
| Chemical Properties | Back Directory | [Boiling point ]
941.8±75.0 °C(Predicted) | [density ]
2.78±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
H2O: 5 mg/mL
| [form ]
lyophilized powder
| [pka]
0.97±0.70(Predicted) | [color ]
white
| [Water Solubility ]
H2O: 5mg/mL |
| Hazard Information | Back Directory | [Chemical Properties]
white lyophilized powder | [Uses]
8-Br-cADPR is a potent cADPR antagonist. 8-Br-cADPR reduces renal damage and the expression of caspase-3 and TRPM2[1]. | [Biochem/physiol Actions]
An antagonist of cyclic ADP-ribose (cADPR), and an endogenous metabolite of β-NAD+. cADPR has been shown to regulate calcium release from the endoplasmic and sarcoplasmic reticulum. In cells, cADPR is synthesized by ADP-ribosyl cyclase or CD38, a lymphocyte differentiation antigen. | [References]
[1] Eraslan E, et al. 8-Br-cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia-reperfusion injury. J Cell Physiol. 2019 Apr;234(4):4572-4581. DOI:10.1002/jcp.27236 |
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