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ChemicalBook--->CAS DataBase List--->1504588-00-4

1504588-00-4

1504588-00-4 Structure

1504588-00-4 Structure
IdentificationBack Directory
[Name]

NAB 2
[CAS]

1504588-00-4
[Synonyms]

NAB 2
alphaSYN-IN-NAB2
NAB2 >=98% (HPLC)
alphaSYN inhibitor NAB2
alphaSYN inhibitor-NAB2
N-[(2-Chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide
N-[(2-chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-1,3-benzodiazole-5-carboxamide
[Molecular Formula]

C23H20ClN3O
[MOL File]

1504588-00-4.mol
[Molecular Weight]

389.88
Chemical PropertiesBack Directory
[density ]

1.24±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 5 mg/mL
[form ]

A crystalline solid
[pka]

13.04±0.46(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H319-H413
[Precautionary statements ]

P264-P280-P305+P351+P338-P337+P313P
Hazard InformationBack Directory
[Description]

alphaSYN-IN-NAB2 is an inhibitor of α-synuclein mutations. It acts by reversing the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons and promoting E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport..
[Uses]

NAB2 is a neuroprotectant that targets the small GTPase Rab1a. NAB2 selectively binds to the GDP-bound form of Rab1a and protects multiple cell types from α-synuclein toxicity by increasing Rab1a expression. Rab1a regulates ER-to-Golgi trafficking and mediates endosomal trafficking events of the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 stimulates ubiquitination of related proteins in a Nedd4-dependent manner and rescues α-synuclein-associated trafficking defects associated with early-onset Parkinson's disease[1][2][3].
[Definition]

ChEBI:N-(2-chlorobenzyl)-1-(2,5-dimethylphenyl)benzimidazole-5-carboxamide is an aromatic amide obtained by the formal condensation of the carboxy group of 1-(2,5-dimethylphenyl)benzimidazole-5-carboxylic acid with the amino group of 2-chlorobenzylamine. It is a member of benzimidazoles, an aromatic amide, a monocarboxylic acid amide and a member of monochlorobenzenes.
[IC 50]

α-synuclein
[storage]

Store at -20°C
[References]

[1] Tardiff DF, et al. Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science. 2013;342(6161):979-983. DOI:10.1126/science.1245321
[2] Hatstat AK, et al. Chemoproteomic-enabled characterization of small GTPase Rab1a as a target of an N-arylbenzimidazole ligand's rescue of Parkinson's-associated cell toxicity. RSC Chem Biol. 2021 Nov 9;3(1):96-111. DOI:10.1039/d1cb00103e
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