| Identification | Back Directory | [Name]
Methyl N-Boc-piperidine-3-carboxylate | [CAS]
148763-41-1 | [Synonyms]
METHYL N-BOC-NIPECOTATE
N-Boc- Piperidine-3-carboxylate
N-Boc-nipecotic acid methyl ester
Methyl N-Boc-piperidine-3-carboxylate
N-Boc-piperidine-3-carboxylate Methyl
1-Boc-3-piperidinecarboxylic Acid Methyl Ester
TERT-BUTYL METHYL PIPERIDINE-1,3-DICARBOXYLATE
REF DUPL: Methyl N-Boc-piperidine-3-carboxylate
N-Boc-piperidine-3-carboxylic acid Methyl ester
1-TERT-BUTYL 3-METHYL PIPERIDINE-1,3-DICARBOXYLATE
Piperidine-1,3-dicarboxylic Acid 1-tert-Butyl 3-Methyl
Methyl 1-(tert-Butoxycarbonyl)-3-piperidinecarboxylate
Methyl 1-(tert-butoxycarbonyl)-3-piperidinedicarboxylate
1-[(tert-butoxy)carbonyl]-2-Methylpiperidine-3-carboxylate
1-(tert-Butoxycarbonyl)-3-piperidinecarboxylic Acid Methyl Ester
piperidine-1,3-dicarboxylic acid O1-tert-butyl ester O3-methyl ester
1,3-Piperidinedicarboxylic acid, 1-(1,1-diMethylethyl) 3-Methyl ester
N-Boc-Piperidine-3-carboxylate or 1-N-BOC-3-piperidinecarboxylic acid Methyl ester | [Molecular Formula]
C12H21NO4 | [MDL Number]
MFCD06795926 | [MOL File]
148763-41-1.mol | [Molecular Weight]
243.3 |
| Chemical Properties | Back Directory | [Melting point ]
47.0 to 51.0 °C | [Boiling point ]
307.4±35.0 °C(Predicted) | [density ]
1.094±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
powder to crystal | [pka]
-2.48±0.40(Predicted) | [color ]
White to Light yellow | [InChI]
InChI=1S/C12H21NO4/c1-12(2,3)17-11(15)13-7-5-6-9(8-13)10(14)16-4/h9H,5-8H2,1-4H3 | [InChIKey]
LYYJQMCPEHXOEW-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCCC(C(OC)=O)C1 |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Synthesis]
Trimethylsilylated diazomethane (14.18 ml, 2.0 M, 28.35 mmol) was added slowly and dropwise to a 20% methanol/toluene (100 ml) solution of 1-BOC-piperidine-3-carboxylic acid (5.00 g, 21.81 mmol) at room temperature. The reaction was monitored by thin layer chromatography (TLC) until the reaction was completed. After completion of the reaction, the reaction mixture was concentrated under reduced pressure to afford methyl N-Boc-3-piperidinecarboxylate (Intermediate 53) 4.44 g in 83.7% yield. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δppm 1.4 (s, 9H), 1.6 (d, J = 3.4 Hz, 1H), 1.6 (m, 1H), 1.7 (m, 1H), 2.0 (m, 1H), 2.4 (m, 1H), 2.8 (m, 1H), 3.0 (s, 1H), 3.7 (s, 3H) , 3.9 (d, J13.2 Hz, 1H), 4.1 (s, 1H). | [References]
[1] Patent: US2006/116376, 2006, A1. Location in patent: Page/Page column 16
[2] Patent: WO2011/141728, 2011, A1. Location in patent: Page/Page column 19-20 |
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