| Identification | Back Directory | [Name]
kynostatin 272 | [CAS]
147318-81-8 | [Synonyms]
KNI272
KNI-272
NSC-651714
kynostatin 272
4-Thiazolidinecarboxamide, N-(1,1-dimethylethyl)-3-[(2S,3S)-2-hydroxy-3-[[(2R)-2-[[(5-isoquinolinyloxy)acetyl]amino]-3-(methylthio)-1-oxopropyl]amino]-1-oxo-4-phenylbutyl]-, (4R)-
kynostatin-272|(R)-N-tert-butyl-3-[(2S,3S)-3-[(S)-2-(5-isoquinolinyloxyacetyl)aMino-3-Methylthiopropionyl]aMino-2-hydroxy-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxaMide|KNI-272|(R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[(R)-2-(5-isoquinolyl
oxy-acetyl)aM | [Molecular Formula]
C33H41N5O6S2 | [MDL Number]
MFCD00913222 | [MOL File]
147318-81-8.mol | [Molecular Weight]
667.84 |
| Chemical Properties | Back Directory | [Boiling point ]
1045.3±65.0 °C(Predicted) | [density ]
1.1345 (rough estimate) | [refractive index ]
1.6460 (estimate) | [pka]
12.44±0.46(Predicted) | [Water Solubility ]
4.2mg/L(25 ºC) |
| Hazard Information | Back Directory | [Uses]
Kynostatin 272 (KNI 272) is a potent HIV protease inhibitor. Kynostatin 272 inhibits the activity of the HIV protease by simulating the substrate transition state of the HIV protease, thus preventing a key step in the replication of the HIV virus. Kynostatin 272 provides an important research foundation for the development of drugs for HIV and AIDS[1][2]. | [Definition]
ChEBI: Kynostatin 272 is a peptide. | [References]
[1] Kimura T, et al. Rigid backbone moiety of KNI-272, a highly selective HIV protease inhibitor: methanol, acetone and dimethylsulfoxide solvated forms of 3-[3-benzyl-2-hydroxy-9-(isoquinolin-5-yloxy)-6-methylsulfanylmethyl-5, 8-dioxo-4, 7-diazanonanoyl]-N-tert-butyl-1, 3-thiazolidine-4-carboxamide[J]. Acta Crystallographica Section B: Structural Science, 2004, 60(4): 433-437.
[2] Freedberg D I, et al. Flexibility and function in HIV protease: Dynamics of the HIV-1 protease bound to the asymmetric inhibitor kynostatin 272 (KNI-272)[J]. Journal of the American Chemical Society, 1998, 120(31): 7916-7923. |
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