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ChemicalBook--->CAS DataBase List--->146797-82-2

146797-82-2

146797-82-2 Structure

146797-82-2 Structure
IdentificationBack Directory
[Name]

ARACHIDONOYL THIO-PC
[CAS]

146797-82-2
[Synonyms]

Thiopc
ARACHIDONOYL THIO-PC
YDSCLGYBUIDZNF-WWBBCYQPSA-N
2-DEOXY-2-THIO ARACHIDONOYL PC
Arachidonoyl thio-PC (substrate)
2-DEOXY-2-THIOARACHIDONOYLPHOSPHATIDYLCHOLINE
1-hexadecyl-2-arachidonoylthio-2-deoxyglycero-3-phosphorylcholine
1-Hexadecyl-2-arachidonoylthio-2-deoxy-sn-glycero-3-phosphorylcholine
1-O-HEXADECYL-2-DEOXY-2-THIO-R-(5Z,8Z,11Z,14Z-EICOSATETRAENOYL)-SN-GLYCERYL-3-PHOSPHORYLCHOLINE
[Molecular Formula]

C44H82NO6PS
[MDL Number]

MFCD00797668
[MOL File]

146797-82-2.mol
[Molecular Weight]

784.16
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 25 mg/ml; DMSO: 25 mg/ml; Water: 0.5 mg/ml
[form ]

Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Description]

Arachidonoyl thio-PC is a substrate for many phospholipase A2s (PLA2s) including sPLA2, cPLA2, and iPLA2. Cleavage of the sn-2 fatty acid by PLA2 results in generation of a free thiol which reacts with chromogenic reagents such as DTNB (Ellman’s reagent) and DTP to allow quantitation of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by excluding or inhibiting sPLA2 and iPLA2 activities in the assay.
[Uses]

Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay.
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