501-53-1

929-06-6

145881-74-9

Diethylene glycolamine (250 ml, 2340 mmol) and 2-methyltetrahydrofuran (1010 ml) were added to a 3-necked 3L flask equipped with an overhead stirrer, a dosing funnel, an N?inlet, and a temperature probe, and the mixture was cooled in an ice bath. A solution of 2-methyltetrahydrofuran (323 ml) of benzyl chloroformate (167 ml, 1125 mmol) was added slowly and dropwise over a period of 40 min, keeping the reaction temperature below 10 °C. The reaction mixture was stirred at room temperature for 1 hour after which a 1M hydrochloric acid solution of ethyl acetate (90 ml, 90 mmol) was added to it and stirring was continued for 30 minutes. The resulting white solid was removed by filtration through a filter pad lined with Solka Floc/Celite, and the filtrate was concentrated under vacuum to afford benzyl [2-(2-hydroxyethoxy)-ethyl]-carbamate (228 g, quantitatively) as a light yellow oil.