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ChemicalBook--->CAS DataBase List--->145808-47-5

145808-47-5

145808-47-5 Structure

145808-47-5 Structure
IdentificationBack Directory
[Name]

MARGATOXIN
[CAS]

145808-47-5
[Synonyms]

MGTX
RMGTX
MARGATOXIN
RMARGATOXIN
MGTX (SCORPION)
MARGATOXIN (MGTX)
BARK SCORPION VENOM
MARGATOXIN (SCORPION)
MARGATOXIN, RECOMBINANT
SCORPION VENOM CENTRUROIDES SCULPTURATUS
MARGATOXIN SCORPION, CENTRUROIDES*MARGAR ITATUS
margatoxin from centruroides margaritatus (scorpion)
MARGATOXIN >97%PURITY \ SPECIFIC K(V)1.3 CHANNEL K+CHANNEL BLOCKER
THR-ILE-ILE-ASN-VAL-LYS-CYS-THR-SER-PRO-LYS-GLN-CYS-LEU-PRO-PRO-CYS-LYS-ALA-GLN-PHE-GLY-GLN-SER-ALA-GLY-ALA-LYS-CYS-MET-ASN-GLY-LYS-CYS-LYS-CYS-TYR-PRO-HIS
H-THR-ILE-ILE-ASN-VAL-LYS-CYS-THR-SER-PRO-LYS-GLN-CYS-LEU-PRO-PRO-CYS-LYS-ALA-GLN-PHE-GLY-GLN-SER-ALA-GLY-ALA-LYS-CYS-MET-ASN-GLY-LYS-CYS-LYS-CYS-TYR PRO-HIS-OH
H-Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His-OH
[Molecular Formula]

C178H286N52O50S7
[MDL Number]

MFCD00132225
[MOL File]

145808-47-5.mol
[Molecular Weight]

4178.95
Questions And AnswerBack Directory
[Uses]

Margatoxin is a highly pure, synthetic, and biologically active peptide toxin.
Chemical PropertiesBack Directory
[storage temp. ]

-20°C
[form ]

Powder
[color ]

White to off-white
[Water Solubility ]

Soluble to 0.50 mg/ml in water
[Sequence]

Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His (Disulfide bridge:Cys7-Cys29;Cys13-Cys34;Cys17-Cys36)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H312-H332
[Precautionary statements ]

P261-P280h-P301+P312a-P304+P340-P321-P501a
[Safety Statements ]

22
[WGK Germany ]

3
Hazard InformationBack Directory
[Biochem/physiol Actions]

Margatoxin is an α-KTx toxin, which is majorly used in ion channel research. It is a 39-amino acid peptide, which is a specific K(V)1.3 channel voltage-dependent K+ channel blocker. Margatoxin is an immunosuppressant that is isolated from the venom of the scorpion Centruroides margaritatus.
[in vivo]

Margatoxin (i.p.; 1 pmol/g) significantly decreases thiogycollate-induced leukocyte transmigration in the peritoneal cavity in 12-week-old C57BL6/J mice[2].

[storage]

-20°C
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