| Identification | Back Directory | [Name]
CIS-ENTACAPONE | [CAS]
145195-63-7 | [Synonyms]
(Z)-Entacapone
CIS-ENTACAPONE
Entacapen impurity A
Entacapone-d10 (cis)
Entacapone impurity A
Entacapone impurity A -I
Entacapone EP IMpurity A
Entacapone impurity A CRS
Entacapone Related CoMpound A
Z Entacapone/ EP impurity A/RC A
Entacapone USP Related Compound A
(2Z)-2-Cyano-3-(3,4-dihydroxy-5-nit
Entacapone EP Impurity A (cis-Entacapone)
Entacapone Impurity 1（Entacapone EP Impurity A）
Entacapone Impurity 17(Entacapone EP Impurity A)
(Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide
(Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
(2Z)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
(2Z)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2Z)-
Entacapone Related Compound A (25 mg) ((Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide)
Entacapone Related Compound A ((Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide) (1235944) | [Molecular Formula]
C14H15N3O5 | [MDL Number]
MFCD00869878 | [MOL File]
145195-63-7.mol | [Molecular Weight]
305.29 |
| Chemical Properties | Back Directory | [Melting point ]
142-144°C | [Boiling point ]
526.6±50.0 °C(Predicted) | [density ]
1.392±0.06 g/cm3(Predicted) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under Inert Atmosphere | [solubility ]
Dichloromethane (Slightly), Methanol (Slightly) | [form ]
neat | [pka]
5.15±0.50(Predicted) | [color ]
Yellow to Orange |
| Hazard Information | Back Directory | [Description]
cis-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor entacapone . It is also a potential impurity found in commercial preparations of entacapone and a degradant of entacapone formed by UV light exposure. | [Chemical Properties]
Orange Solid | [Uses]
(Z)-Isomer of Entacapone polymorphic form B. Antiparkinsonian | [Uses]
cis-Entacapone (Entacapone EP Impurity A) is the (Z)-Isomer of Entacapone polymorphic form B. Antiparkinsonian. | [Definition]
ChEBI: 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide is a hydroxycinnamic acid. |
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