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ChemicalBook--->CAS DataBase List--->1446971-41-0

1446971-41-0

1446971-41-0 Structure

1446971-41-0 Structure
IdentificationBack Directory
[Name]

D-Valine, N-(3-methoxy-1,3-dioxopropyl)-, methyl ester
[CAS]

1446971-41-0
[Synonyms]

D-Valine, N-(3-methoxy-1,3-dioxopropyl)-, methyl ester
[Molecular Formula]

C10H17NO5
[MOL File]

1446971-41-0.mol
[Molecular Weight]

231.25
Chemical PropertiesBack Directory
[Boiling point ]

350.1±22.0 °C(Predicted)
[density ]

1.115±0.06 g/cm3(Predicted)
[pka]

12.22±0.46(Predicted)
Hazard InformationBack Directory
[Uses]

ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain. ZLc-002 can be used for the research of anxiety disorder and inflammation[1][2][3].
[in vivo]

ZLc-002 (30 mg/kg; i.p. from 4-10 days until 46 days after stroke everyday) improves motor function in tMCAO mice[1]. ZLc-002 (40 mg/kg; i.v. once per day for seven days) improves chronic mild stress (CMS)-induced anxiety-related behaviours[2]. ZLc-002 (10 μM 1 μL; hippocampus injection once per day for seven days) improves corticosterone (CORT)-induced anxiety-related behaviours[2].

Animal Model:tMCAO mice[2]
Dosage:30 mg/kg
Administration:Intraperitoneal injection; 30 mg/kg per day; from 4–10 days until 46 days after stroke
Result:Signally ameliorated sroke-induced impairment of motor function and recovered from stroke in the delayed phase.
Animal Model:Adult male ICR mice with CMS exposure[2]
Dosage:40 mg/kg
Administration:Intravenous injection; 40 mg/kg once per day; from 21-27 days of CMS exposure for 7 days
Result:Showed a therapeutic effect in CMS-induced anxiety disorder.
Animal Model:Adult male ICR mice with CORT[2]
Dosage:10 μM 1 μL
Administration:Hippocampus injection; 10 μM 1 μL once per day; from 21-27 days of CORT reatmentfor 7 days
Result:Showed a therapeutic effect in chronic stress-induced anxiety disorders.
[References]

[1] Ni HY, et al.Dissociating nNOS (Neuronal NO Synthase)-CAPON (Carboxy-Terminal Postsynaptic Density-95/Discs Large/Zona Occludens-1 Ligand of nNOS) Interaction Promotes Functional Recovery After Stroke via Enhanced Structural Neuroplasticity. Stroke. 2019 Mar;50(3):728-737. DOI:10.1161/STROKEAHA.118.022647
[2] Zhu LJ, et al. nNOS-CAPON blockers produce anxiolytic effects by promoting synaptogenesis in chronic stress-induced animal models of anxiety. Br J Pharmacol. 2020 Aug;177(16):3674-3690. DOI:10.1111/bph.15084
[3] Zhu LJ, et al.CAPON-nNOS coupling can serve as a target for developing new anxiolytics. Nat Med. 2014 Sep;20(9):1050-4. doi: 10.1038/nm.3644. Epub 2014 Aug 17. DOI:10.1038/nm.3644
1446971-41-0 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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