| Chemical Properties | Back Directory | [Boiling point ]
643.9±55.0 °C(Predicted) | [density ]
1.210±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.70±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
OP-1074, a pure anti-estrogen drug, is a selective ER degrader (PA-SERD) with specific anti-estrogenic activity against ERα and ERβ, inhibiting 17β-estradiol (E2)-stimulated transcription with IC50 values of 1.6 and 3.2 nM, respectively. | [IC 50]
ERα; ERβ | [References]
[1] Fanning SW, et al. Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.Nat Commun. 2018 Jun 18;9(1):2368. DOI:10.1038/s41467-018-04413-3 |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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