| Identification | Back Directory | [Name]
aglafoline | [CAS]
143901-35-3 | [Synonyms]
aglafolin
aglafoline
Rocaglamide U
(-)-Methyl rocaglate
1H-Cyclopenta[b]benzofuran-2-carboxylic acid, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-, methyl ester, (1R,2R,3S,3aR,8bS)- | [Molecular Formula]
C28H28O8 | [MDL Number]
MFCD14635394 | [MOL File]
143901-35-3.mol | [Molecular Weight]
492.52 |
| Chemical Properties | Back Directory | [Melting point ]
92-93 °C(Solv: benzene (71-43-2); hexane (110-54-3)) | [Boiling point ]
622.9±55.0 °C(Predicted) | [density ]
1.348±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Ethanol : 100 mg/mL (203.04 mM) | [form ]
Solid | [pka]
11?+-.0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Aglafoline inhibits PAF-induced platelet aggregation, with an IC50 value of 50 μM. | [Definition]
ChEBI: A heterotricyclic compound based on a 2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan framework substituted by hydroxy groups at positions C-1 and C-8b, a methoxycarbonyl group at C-2, a phenyl group at C-3,
4-methoxyphenyl group at C-3a and methoxy groups at C-6 and C-8. A platelet aggregation inhibitor found in Aglaia elliptifolia and Aglaia odorata. | [References]
[1] Ko FN, et al. PAF antagonism in vitro and in vivo by aglafoline from Aglaia elliptifolia Merr. Eur J Pharmacol. 1992 Jul 21;218(1):129-35. DOI:10.1016/0014-2999(92)90156-x |
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