| Identification | Back Directory | [Name]
L 012 | [CAS]
143323-55-1 | [Synonyms]
8-Amino-5-chloro-7-phenyl-2,3-dihydropyrido[3,4-d]pyridazine-1,4-dione
Pyrido[3,4-d]pyridazine-1,4-dione, 8-amino-5-chloro-2,3-dihydro-7-phenyl- | [Molecular Formula]
C13H9ClN4O2 | [MDL Number]
MFCD03457287 | [MOL File]
143323-55-1.mol | [Molecular Weight]
288.69 |
| Hazard Information | Back Directory | [Uses]
L-012 is a chemiluminescent probe that reacts with various types of ROS produced by activated neutrophils in human blood, oral cavity, and rat peritoneum and produces strong chemiluminescence (CHL). L-012 produces CHL primarily by reacting with hydroxyl radicals and hypochlorite. L-012 can be used to study ROS generation in complex biological systems and the role of ROS in the pathogenesis of various diseases[1]. | [References]
[1] Imada I, et al. Analysis of reactive oxygen species generated by neutrophils using a chemiluminescence probe L-012[J]. Analytical biochemistry, 1999, 271(1): 53-58. DOI:10.1006/abio.1999.4107
[2] Zielonka J, et al. On the use of L-012, a luminol-based chemiluminescent probe, for detecting superoxide and identifying inhibitors of NADPH oxidase: a reevaluation. Free Radic Biol Med. 2013;65:1310-1314. DOI:10.1016/j.freeradbiomed.2013.09.017
[3] Kielland A, et al. In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012. Free Radic Biol Med. 2009;47(6):760-766. DOI:10.1016/j.freeradbiomed.2009.06.013 |
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