午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

ChemicalBook--->CAS DataBase List--->1432436-13-9

1432436-13-9

1432436-13-9 Structure

1432436-13-9 Structure
IdentificationBack Directory
[Name]

VU0453595
[CAS]

1432436-13-9
[Synonyms]

VU453595
VU0453595
[Molecular Formula]

C18H15FN4O
[MDL Number]

MFCD34179472
[MOL File]

1432436-13-9.mol
[Molecular Weight]

322.34
Chemical PropertiesBack Directory
[Boiling point ]

552.8±50.0 °C(Predicted)
[density ]

1.35±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 100 mg/mL (310.23 mM; Need ultrasonic)
[form ]

Solid
[pka]

2.98±0.20(Predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

VU0453595 is a highly selective, systemically active M1 positive allosteric modulator (PAM, EC50=2140?nM) for the research of schizophrenia[1][2].
[Biological Activity]

VU0453595 is a highly selective, systemically active M1 positive allosteric modulator (PAM, EC50=2140 nM) for the research of schizophrenia[1][2]. Application of M1 PAM VU0453595 (3 μM) induces a transient increase in excitability of medium spiny neurons (MSNs)[3]. VU0453595 potentiates M1-mediated muscarinic long-term depression (mLTD)[1].VU0453595 (1-10 mg/kg; i.p.) reverses behavioral deficits induced by repeated phencyclidine (PCP) administration[1].
[in vivo]

VU0453595 potentiates M1-mediated muscarinic long-term depression (mLTD)[1].
VU0453595 (1-10?mg/kg; i.p.) reverses behavioral deficits induced by repeated phencyclidine (PCP) administration[1].

Animal Model:Male C57BL6/J mice (8-9 weeks old)[1]
Dosage:1, 3, or 10?mg/kg
Administration:Intraperitoneal (i.p.); 10?mL/kg; administered 30?min before the social interaction test
Result:Rescued deficits in social interaction observed in PCP-treated mice.
[storage]

Store at -20°C
[References]

[1]. A Ghoshal, et al. Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model. Neuropsychopharmacology. 2016 Jan;41(2):598-610. [2]. Sean P Moran, et al. M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition. Neuropsychopharmacology. 2018 Jul;43(8):1763-1771. [3]. Xiaohui Lv, et al. M1 muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons. Neuropharmacology. 2017 May 15;118:209-222.
1432436-13-9 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website: www.targetmol.com/
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105 , +1-13798911105
Website: https://www.invivochem.com/
Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 021-61312847; 18021002903
Website: http://www.shyuanye.com
Company Name: ShangHai Biochempartner Co.,Ltd  
Tel: 177-54423994 17754423994
Website: www.biochempartner.com
Company Name: Shanghai SuperLan Chemcial Technique Centre  
Tel: 021-2022843681 15618226720
Website: www.yuhua99.com/ShowSupplierProductsList19886/0_EN.htm
Company Name: Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd  
Tel: 15317229551
Website: https://www.ureiko.com
Company Name: Bide Pharmatech Ltd.  
Tel: 400-1647117 13681763483
Website: https://www.bidepharm.com/
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310
Website: https://www.targetmol.cn/
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: Shanghai jerryxing Biomedical Technology Co., Ltd  
Tel: 17721492509; 17721492509
Website: http://www.jrxbiochem.com/
Company Name: Sangon Biotech (Shanghai) Co.,Ltd.  
Tel: 400-821-026
Website: www.sangon.com
Company Name: Absin Bioscience Inc.  
Tel: 021-38015121-8802
Website: http://www.absin.cn
Company Name: Proteintech China  
Tel: 027-87531629
Website: http://www.ptgcn.com
Company Name: Guangzhou Suyan Biotechnology Co., Ltd   
Tel: 18818417021
Website: https://www.gzsuyan.com/col.jsp?id=144
Company Name: Guangzhou Lucheng Biotechnology Co., Ltd.  
Tel: 16620452357
Website: http://www.gzlucheng.com.cn/
Company Name: Nanjing Shizhou Biology Technology Co.,Ltd  
Tel: 025-85560043 15850508050
Website: http://www.synzest.com
Tags:1432436-13-9 Related Product Information
1819356-87-0 1638646-27-1 38376-29-3 1439095-16-5 1246086-78-1 1396749-92-0 1274859-33-4 1309976-62-2 312622-77-8 1135243-19-4 1246303-14-9 1816301-67-3 85511-68-8 1623101-11-0 2126040-21-7 1296731-74-2 1093757-42-6

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.