| Identification | Back Directory | [Name]
SB408124 Hydrochloride | [CAS]
1431697-90-3 | [Synonyms]
SB-408124 HCl
SB408124 Hydrochloride
SB 408124 Hydrochloride
SB-408124 (Hydrochloride)
SB 408124 HYDROCHLORIDE;SB408124 HYDROCHLORIDE
N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]urea hydrochloride (1:1) | [Molecular Formula]
C19H19ClF2N4O | [MDL Number]
MFCD19443231 | [MOL File]
1431697-90-3.mol | [Molecular Weight]
392.83 |
| Hazard Information | Back Directory | [Uses]
SB 408124 Hydrochloride is a salt form of SB 40812 (S155088), which 4 is a novel OX-1 antagonist. | [in vivo]
SB-408124 reduces anxiety after psychotraumatic exposure. Predator induces acute psychotraumatic exposure decrease corticoliberin level in the rat's amygdala. Intranasal administration of SB-408124 restores it closely to normal and has an anxiolytic effect on animal behaviour[2].
Bilateral paraventricular nucleus microinjection of SB-408124 (30 pmol/50 nL per side) results in a greater reduction in mean arterial pressure (MAP) in high-salt intake (-16?mmHg) compared with NS-fed (-4?mmHg) anesthetized Dahl salt-sensitive rats[3]. | [IC 50]
OX1 Receptor: 57 nM (Ki, in whole cell ); OX1 Receptor: 27 nM (Ki, in cell membrane) | [storage]
Store at -20°C |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|