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ChemicalBook--->CAS DataBase List--->1423126-69-5

1423126-69-5

1423126-69-5 Structure

1423126-69-5 Structure
IdentificationBack Directory
[Name]

YLL545
[CAS]

1423126-69-5
[Synonyms]

YLL545
Urea, N-[4-(1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)phenyl]-N′-[3-(trifluoromethyl)phenyl]-
[Molecular Formula]

C19H13F3N6O2
[MOL File]

1423126-69-5.mol
[Molecular Weight]

414.34
Chemical PropertiesBack Directory
[Boiling point ]

490.013±45.00 °C(Press: 760.00 Torr)(predicted)
[density ]

1.557±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[pka]

9.488±0.23(predicted)
Hazard InformationBack Directory
[Uses]

YLL545 is a type of vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor. YLL545 can inhibit VEGF-induced phosphorylation of VEGFR2 and the activation of downstream signaling factors (like phosphorylated STAT3 and phosphorylated ERK1/2) in human umbilical vein endothelial cells (HUVEC). YLL545 can suppress the proliferation, migration, invasion, and angiogenesis of HUVEC. YLL545 can induce apoptosis in breast cancer mice and inhibit tumor growth[1].
[References]

[1] Zhang J, et al. The novel VEGF receptor 2 inhibitor YLL545 inhibits angiogenesis and growth in breast cancer. Oncotarget. 2016 Jul 5;7(27):41067-41080. DOI:10.18632/oncotarget.9392
1423126-69-5 suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 021-13816613772 13816613772
Website: www.yuhua99.com/ShowSupplierProductsList16976/0_EN.htm
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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