| Identification | Back Directory | [Name]
Pyrrolo[2,1-b][1,3]oxazepine-7-carboxamide, octahydro-8,8-dimethyl-4-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-5-oxo-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-, (4S,7S,9aS)- | [CAS]
1422180-49-1 | [Synonyms]
SB1-0636457
SBI-0636457
SBP-0636457
Pyrrolo[2,1-b][1,3]oxazepine-7-carboxamide, octahydro-8,8-dimethyl-4-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-5-oxo-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-, (4S,7S,9aS)- | [Molecular Formula]
C25H36N4O4 | [MOL File]
1422180-49-1.mol | [Molecular Weight]
456.58 |
| Chemical Properties | Back Directory | [Boiling point ]
733.0±60.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, stored under nitrogen | [form ]
Solid | [pka]
13.92±0.60(Predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Uses]
SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins, with a Ki of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers[1][2]. | [Biological Activity]
SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins, with a Ki of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers[1][2].
SBP-0636457 (1-20 μM) demonstrates no cytotoxicity in BT474, BT549, MCF7, and MDA-MB-231 breast cancer cell lines up to a concentration of 20μM[1].SBP-0636457 (10-1000 nM; 20 h) is ef?cacious as TRAIL-sensitizing agents in MDA-MB-231 cells, with an EC50 of 9 nM[1]. | [IC 50]
XIAP: 0.27 μM (Ki) | [storage]
4°C, stored under nitrogen | [References]
[1]. Finlay D, et, al. Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs. Mol Cancer Ther. 2014 Jan; 13(1): 5-15. [2]. Finlay D, et, al. Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins. F1000Res. 2017 Apr 27; 6:587. |
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