| Identification | Back Directory | [Name]
PC Mal-NHS carbonate ester | [CAS]
1408057-91-9 | [Synonyms]
PC Mal-NHS carbonate ester
Carbonic acid, 1-[4-[4-[[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethyl]amino]-4-oxobutoxy]-5-methoxy-2-nitrophenyl]ethyl 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C24H26N4O12 | [MDL Number]
MFCD30458017 | [MOL File]
1408057-91-9.mol | [Molecular Weight]
562.48 |
| Chemical Properties | Back Directory | [density ]
1.49±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Solid | [pka]
15.25±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
PC Mal-NHS carbonate ester is a photocleavable linker containing a Maleimide and an NHS ester groups. The maleimide group can react with thiol groups between pH 6.5 to 7.5. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. | [Uses]
PC Mal-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [IC 50]
Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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