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ChemicalBook--->CAS DataBase List--->1404-59-7

1404-59-7

1404-59-7 Structure

1404-59-7 Structure
IdentificationBack Directory
[Name]

Rutamycin
[CAS]

1404-59-7
[Synonyms]

A-272
RR-32705
Rutamycin
RRNo-32705
oligomycin D
26-Demethyloligomycin A
RutaMycin, 26-deMethyloligoMycin A, A 272, RR 32705, RutaMycin A
[Molecular Formula]

C44H72O11
[MDL Number]

MFCD32640222
[MOL File]

1404-59-7.mol
[Molecular Weight]

777.042
Chemical PropertiesBack Directory
[Melting point ]

116-119°
[alpha ]

D20 -62° (c = 1.36 in CHCl3)
[storage temp. ]

Store at -20°C
[solubility ]

DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
[form ]

A lyophilisate
Safety DataBack Directory
[RIDADR ]

2811
[HazardClass ]

6.1(b)
[PackingGroup ]

III
[Toxicity]

LD50 oral in mouse: 800mg/kg
Hazard InformationBack Directory
[Description]

Oligomycin D is a macrolide antibiotic produced by several species of Streptomyces that inhibits the mitochondrial F1FO-ATPase and is used to uncouple oxidative phosphorylation from electron transport. Oligomycin D is reported to inhibit K-Ras plasma membrane localization in MDCK cells with an IC50 value of 3.49 nM and is cytotoxic to SW620 colon cancer cells with an IC50 value of 36 μM.
[Uses]

Oligomycin D (rutamycin) is macrocyclic lactone belonging to the oligomycin class but identified from different species of Streptomyces in 1961. Like oligomycin A, oligomycin D inhibits mitochondrial F1F0-ATPase and is an important bioprobe to study the organisation of ATPase on the mitochondrial membrane. Oligomycin D exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.
[Uses]

Oligomycin D is an inhibitor of mitochondrial F1F0-ATPase.
[storage]

Store at -20°C
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