| Identification | Back Directory | [Name]
Sarolaner | [CAS]
1398609-39-6 | [Synonyms]
PF6450567
Sarolaner
PF 6450567
PF 6450567;PF6450567
Sarolaner(PF-6450567)
dog,Sarolaner,Parasite,PF 6450567,flea,Inhibitor,oral,inhibit,isoxazoline,tick,PF6450567
1-[6-[(5S)-5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]spiro[1H-2-benzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone
(S)-1-(5'-(5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone
Ethanone, 1-[5'-[(5S)-5-(3,5-dichloro-4-fluorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]spiro[azetidine-3,1'(3'H)-isobenzofuran]-1-yl]-2-(methylsulfonyl)- | [Molecular Formula]
C23H18Cl2F4N2O5S | [MDL Number]
MFCD28963963 | [MOL File]
1398609-39-6.mol | [Molecular Weight]
581.36 |
| Chemical Properties | Back Directory | [Boiling point ]
722.7±70.0 °C(Predicted) | [density ]
1.65±0.1 g/cm3(Predicted) | [storage temp. ]
Store at 4°C, sealed storage, away from moisture | [solubility ]
DMF: Slightly soluble; DMSO: Slightly soluble; Ethanol: Slightly soluble | [form ]
A solid | [pka]
-0.93±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Sarolaner is used in the making of formulations for the control of ticks in cats, and flea infestations in dogs. A parasiiticide. | [in vivo]
Sarolaner (2.5 mg/kg; p.o. once) shows 100% efficacious against R. sanguineus and D. reticulatus[1]. Sarolaner (1.25- 5 mg/kg; p.o. once) effectively against I. ricinus[1]. | Animal Model: | Dog infested with R. sanguineus and D. reticulatus[1] | | Dosage: | 2.5 mg/kg | | Administration: | Oral gavage; 2.5 mg/kg once | | Result: | Exibited 100% efficacy against R. sanguineus at 48 hours after treatment and also exhibited 98.0% efficacy againstD. reticulatus. |
| Animal Model: | Dog infested with I. ricinus[1] | | Dosage: | 1.25, 2.5 and 5 mg/kg | | Administration: | Oral gavage; 1.25, 2.5 and 5 mg/kg once | | Result: | Exibited 100% efficacy against I. ricinus at all doses until 7 days, and provided over 99.3% reduction against subsequent re-infestations until 57 days at dose of 5.0 and 2.5 mg/kg. |
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