| Identification | Back Directory | [Name]
CGP 48664A | [CAS]
138794-73-7 | [Synonyms]
CGP 48664A
Sardomozide HCl
Sardomozide dihydrochloride | [Molecular Formula]
C11H15ClN6 | [MDL Number]
MFCD00910325 | [MOL File]
138794-73-7.mol | [Molecular Weight]
266.73 |
| Chemical Properties | Back Directory | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO:25.0(Max Conc. mg/mL);82.46(Max Conc. mM) | [form ]
A solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CGP 48664A is polyamine synthesis inhibitor. It can be used in biological study and therapeutic use. Discovered antiparasitic drugs may influence spermidine/spermine N-1 acetyl transferase associated with polyamine pathway. | [Biological Activity]
CGP 48664 (SAM486A; Sardomozide) is a polyamine (PA) biosynthesis inhibitor (73% and 97% downregulation of murine leukemia L1210 cellular spermidine and sperminerespectivelyby 0.5 μM Sardomozide in 4 days) th at targets the rate-limiting enzyme S-adenosylmethionine decarboxylase (AdoMetDCSAMDCAMD1) in a potent (IC50 = 5 nM against r at AMD1) and selective manner with little or no inhibitory efficacy toward diamine oxidase or ornithine decarboxylase (IC50 = 18 μM and >50 μM against r at DAO and ODCrespectively). CGP 48664 effectively inhibits the proliferation of murine (GI50 = 0.5 μM against L1210 in 4 days) and human cancer cell lines in cultures (GI50 from 0.26 to 0.6 μM in 5 days; GI50 = 0.8 μM against human melanoma SK MEL-24 in 10 days) and suppresses the growth of murine and human tumor xenografts in mice in vivo (ED50 ≤0.5 mg/kg i.p.). CGP 48664 (Sardomozide) potently inhibits growth of PFA ependymoma cells. |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
| Company Name: |
Twochem Co.Ltd.
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| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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