| Identification | More | [Name]
RHODAMINE 110 | [CAS]
13558-31-1 | [Synonyms]
O-(6-AMINO-3-IMINO-3H-XANTHEN-9-YL)BENZOIC ACID HYDROCHLORIDE
R110
RHODAMIN 110 CHLORIDE
RHODAMINE 110
RHODAMINE 110 CHLORIDE
RHODAMINE 560
RHODAMINE HYDROCHLORIDE
3,6-diamino-9-(2-carboxyphenyl)xanthylium chloride
RHODAMINE 110 CHLORIDE, FOR FLUOR-ESCENC E
Rhodamine 110, laser grade, pure, 99%
2-(6-Amino-3-imino-3H-xanthen-9-yl)-benzoic acid hydrochloride
Exciton Rhodamine 560 Chloride
Rhodamin 110
Rhodamine 110, 99%, laser grade, pure
3,6-Diamino-9-(2-carboxyphenyl)xanthylium | [EINECS(EC#)]
236-944-7 | [Molecular Formula]
C20H15ClN2O3 | [MDL Number]
MFCD00042009 | [Molecular Weight]
366.8 | [MOL File]
13558-31-1.mol |
| Chemical Properties | Back Directory | [Appearance]
red to bordeaux crystals or crystalline powder | [Melting point ]
>300 °C(lit.)
| [density ]
1.2504 (rough estimate) | [refractive index ]
1.6470 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
ethanol: soluble | [form ]
Crystalline Powder | [color ]
White to light yellow | [λmax]
499nm (MeOH); 496nm (H2O) | [BRN ]
4631860 | [Stability:]
Hygroscopic, Light Sensitive | [Biological Applications]
Detecting risk of Alzheimer’s disease and stroke;evaluating/testing sperm quality; identifying bacteria; as a substrate for measuring aromatase activity, azoreductase activity,phospholipase activity, proteases activity (caspase activity, cathepsin C activity, elastase activity proteinase activity);implantable drug-delivery devices | [Major Application]
Color filters; liquid crystal displays; dye lasers;electroluminescent displays;inks;light-emitting diode (LED);papermaking process; recording materials; solar cells; silica thin films;sol–gel titania films;waveguides | [InChI]
InChI=1S/C20H14N2O3.ClH/c21-11-5-7-15-17(9-11)25-18-10-12(22)6-8-16(18)19(15)13-3-1-2-4-14(13)20(23)24;/h1-10H,21-22H2;1H | [InChIKey]
MYIOYATURDILJN-UHFFFAOYSA-N | [SMILES]
C(C1C=CC=CC=1C1C2=CC=C(N)C=C2[O+]=C2C=C(N)C=CC=12)(=O)O.[Cl-] | [CAS DataBase Reference]
13558-31-1(CAS DataBase Reference) | [EPA Substance Registry System]
Xanthylium, 3,6-diamino-9-(2-carboxyphenyl)-, chloride (13558-31-1) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [HS Code ]
29329990 |
| Hazard Information | Back Directory | [Description]
Rhodamine 110 is a green fluorescent cationic dye with excitation and emission maxima of 496 and 520 nm, respectively.1 When incorporated with a hydrolytic substrate (e.g., proteinase or peptidase substrates), it can be used as a highly sensitive detection reagent in fluorescence-based enzyme assays.2 Rhodamine 110 has also been used in a fluorescence quenching method for determining trace nitrite and as a probe for cytochrome P450 activity.3,4 | [Chemical Properties]
red to bordeaux crystals or crystalline powder | [Uses]
Rhodamine 110 is a fluorescent dye used as AP- and exopeptidase substrates for flow cytometric measurements. | [in vivo]
Rhodamine 110 is less toxic than the parent molecule based on the intravenous LD50 acute toxicity values of 89.5 mg/kg and 140.0 mg/kg for Rhodamine B and Rhodamine 110, respectively. Both molecules induce liver and kidney enlargement after ingestion, and male rats show more significant increases than female rats after Rhodamine 110 exposure. In addition, testis weight increased in male rats dosed with Rhodamine 110. The pharmacokinetics of Rhodamine 110 are assessed following oral administration at two dosages (3 and 10 mg/kg) and intravenous administration at one dosage (3 mg/kg). Pharmacokinetic parameters are calculated using an extravascular input and IV-bolus input, noncompartmental model analysis conducted with WinNonlin Standard Edition. The pharmacokinetic parameters of Rhodamine 110 indicates that the maximum plasma concentrations (Cmax) of the two oral dosages are 283.4 and 657.0 ng/mL, which are reached at 140 and 210 min, respectively. This indicates that Rhodamine 110 absorption is not rapid after ingestion, as it took over 2 h to be absorbed from the intestines into the blood. The areas under the concentration–time curves (AUCs) for the two dosages are 138.1±20.3 and 444.0±170.8 h ng/mL. The pharmacokinetic data demonstrate that the AUC is proportional to the administered oral dose of Rhodamine 110 (3 mg/kg and 10 mg/kg). Furthermore, the clearance (Cl) of the two orally administered doses is 7.94 and 8.61 mL/min/kg, respectively[1]. |
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