| Identification | Back Directory | [Name]
Propargyl-PEG4-t-butyl ester | [CAS]
1355197-66-8 | [Synonyms]
1355197-66-8
Propargyl-PEG4-Boc
Propargyl-PEG4-COOtBu
Alkyne-PEG4-CH2CH2COOtBu
PROPARGYL-PEG4-CH2CH2COOTBU
Propargyl-PEG4-t-butyl ester
4,7,10,13-Tetraoxahexadec-15-ynoic acid, 1,1-dimethylethyl ester | [Molecular Formula]
C16H28O6 | [MDL Number]
MFCD22683285 | [MOL File]
1355197-66-8.mol | [Molecular Weight]
316.39 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG4-t-butyl ester enables the formation of a stable triazole linkage with azide compounds or biomolecules via copper catalyzed Click Chemistry reactions. The t-butyl protected carboxyl group can be hydrolyzed under acidic conditions. | [Uses]
Propargyl-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|