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ChemicalBook--->CAS DataBase List--->1354812-99-9

1354812-99-9

1354812-99-9 Structure

1354812-99-9 Structure
IdentificationBack Directory
[Name]

RO 5527239
[CAS]

1354812-99-9
[Synonyms]

RO5527239
RO-5527239
RO 5527239
[Molecular Formula]

C28H31N3O3
[MOL File]

1354812-99-9.mol
[Molecular Weight]

457.56
Chemical PropertiesBack Directory
[Boiling point ]

705.2±60.0 °C(Predicted)
[density ]

1.20±0.1 g/cm3(Predicted)
[pka]

3.85±0.20(Predicted)
Hazard InformationBack Directory
[Description]

RO5527239 is a potent, orally available GPBAR1 agonist.
[Uses]

RO5527239 is an orally active TGR5 agonist, that induces a stimulatory response from intestinal L cells and specificially secrets the endogenous hormone GLP-2[1].
[in vivo]

RO5527239 (30 mg/kg, p.o. for 10 days) stimulates the TGR5 receptor, upregulates L cells and L cells hormone GLP-2, triggers a GLP-2-dependent intestinal adaption in C57BL/6N mice[1].

Animal Model:GLP-2r-/- and GLP-2r+/+ C57Bl/6N mice[1]
Dosage:30 mg/kg
Administration:p.o. for 10 days
Result:Increased GLP-1 and GLP-2 concentrations in the colon, gallbladder weight with both genotype. Increased villus height in the duodenum and decreased colon length in GLP-2r+/+ mice.
[References]

[1] Hunt JE, et al., Pharmacological activation of TGR5 promotes intestinal growth via a GLP-2-dependent pathway in mice. Am J Physiol Gastrointest Liver Physiol. 2020 May 1;318(5):G980-G987. DOI:10.1152/ajpgi.00062.2020
1354812-99-9 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website: www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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