| Identification | Back Directory | [Name]
Chloroacetamido-PEG4-NHS ester | [CAS]
1353011-95-6 | [Synonyms]
Cl-NH-PEG4-NHS
CAS_1353011-95-6
Cl-peg4-nhsester
Chloroacetamido-PEG4-NHS ester
Chloroacetamido-PEG5-NHS ester
2,5-Dioxopyrrolidin-1-yl 1-chloro-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate
Propanoic acid, 3-[(14-chloro-13-oxo-3,6,9-trioxa-12-azatetradec-1-yl)oxy]-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C17H27ClN2O9 | [MDL Number]
MFCD20926381 | [MOL File]
1353011-95-6.mol | [Molecular Weight]
438.86 |
| Hazard Information | Back Directory | [Description]
Chloroacetamido-PEG4-NHS ester is a PEG linker containing chloroacetamide and NHS ester functional groups. The chlorine is a good leaving group and can undergo substitution reactions. The NHS ester is an active ester which reacts with primary amines to form stable amide bonds. The hydrophilic PEG linker increases the hydrophilic properties of the compound in aqueous media. | [Uses]
Chloroacetamido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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Energy Chemical
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| Company Name: |
Wuhan Topule
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http://www.topule.com/ |
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