| Identification | Back Directory | [Name]
poststatin | [CAS]
135219-43-1 | [Synonyms]
poststatin
L-Val-L-Val-[(3S)-2-Oxo-3-amino*pentanoyl]-D-Leu-L-Val-OH
L-Valine, L-valyl-L-valyl-(3S)-3-amino-2-oxopentanoyl-D-leucyl-
N-[N-[(S)-3-[(N-L-Valyl-L-valyl)amino]-1,2-dioxopentyl]-D-leucyl]-L-valine | [Molecular Formula]
C26H47N5O7 | [MDL Number]
MFCD00895422 | [MOL File]
135219-43-1.mol | [Molecular Weight]
541.68 |
| Hazard Information | Back Directory | [Uses]
Poststatin is a pecific prolyl endopeptidase (PEP) inhibitor. Poststatin inhibits bradykinin-degrading enzymes in rat urine[1][2]. | [References]
[1] T Aoyagi, et al. Poststatin, a new inhibitor of prolyl endopeptidase, produced by Streptomyces viridochromogenes MH534-30F3. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1991 Sep;44(9):949-55. DOI:10.7164/antibiotics.44.949
[2] M Majima, et al. Poststatin, a novel inhibitor of bradykinin-degrading enzymes in rat urine. Eur J Pharmacol. 1993 Mar 2;232(2-3):181-90. DOI:10.1016/0014-2999(93)90772-a |
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