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ChemicalBook--->CAS DataBase List--->1352149-24-6

1352149-24-6

1352149-24-6 Structure

1352149-24-6 Structure
IdentificationBack Directory
[Name]

GSK299423
[CAS]

1352149-24-6
[Synonyms]

GSK299423
GSK-229423
GSK-229423 (GSK229423)
GSK 299423|||GSK-299423
3-Quinolinecarbonitrile, 6-methoxy-4-[2-[4-[([1,3]oxathiolo[5,4-c]pyridin-6-ylmethyl)amino]-1-piperidinyl]ethyl]-
[Molecular Formula]

C25H27N5O2S
[MOL File]

1352149-24-6.mol
[Molecular Weight]

461.58
Chemical PropertiesBack Directory
[Boiling point ]

662.8±55.0 °C(Predicted)
[density ]

1.34±0.1 g/cm3(Predicted)
[pka]

7.92±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

GSK 299423 is an antibiotic agent.GSK299423 shows potent inhibition of supercoiling by DNA gyrase from S. aureus(IC50=14 nM）and Escherichia coli(IC50=100 nM[1].
[References]

[1] Bax BD, et al. Type IIA topoisomerase inhibition by a new class of antibacterial agents. Nature. 2010;466(7309):935-940. DOI:10.1038/nature09197
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