| Identification | Back Directory | [Name]
UNC569 | [CAS]
1350547-65-7 | [Synonyms]
UNC569
CS-2399
UNC-569;UNC 569
1H-Pyrazolo[3,4-d]pyrimidin-6-amine, 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)- | [Molecular Formula]
C22H29FN6 | [MDL Number]
MFCD26936336 | [MOL File]
1350547-65-7.mol | [Molecular Weight]
396.5 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 2.5 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml; DMSO: 0.2 mg/ml; Ethanol: 2 mg/ml | [form ]
A crystalline solid | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
UNC 569 induces morphological changes in pigment epithelia and photoreceptor cells in retina through MerTK inhibition in mice. A specific MerTK inhibitor. | [in vivo]
The in vivo pharmacokinetic properties of UNC569 (3 mg/kg) are also assessed in mice via both intravenous (IV) and oral (PO) administration. UNC569 has low systemic clearance (19.5 mL/min/kg), high volume of distribution (Vss of 5.83 L/kg), and good oral bioavailability (57%)[1].
Leukemic zebrafish are treated continuously for 2 weeks by immersion in 4 μM UNC569. the result shows that UNC569 induces more than 50% reduction in tumor burden compared with vehicle- and mock-treated fish[2]. | [IC 50]
Axl; Tyro3; Mer |
|
| Company Name: |
parabiochem
|
| Tel: |
025-83453382-8005 |
| Website: |
www.parabiochem.cn |
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
|