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ChemicalBook--->CAS DataBase List--->1345406-09-8

1345406-09-8

1345406-09-8 Structure

1345406-09-8 Structure
IdentificationBack Directory
[Name]

BPR3P0128
[CAS]

1345406-09-8
[Synonyms]

BPR3P0128
[Molecular Formula]

C22H18BrN3O2
[MOL File]

1345406-09-8.mol
[Molecular Weight]

436.3
Chemical PropertiesBack Directory
[Boiling point ]

607.8±55.0 °C(predicted)
[density ]

1.46±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka]

3.01±0.61(predicted)
Hazard InformationBack Directory
[Uses]

BPR3P0128 is an orally active, non-nucleoside RNA-dependent RNA polymerase (RdRp) inhibitor that has been shown to inhibit the activity of various SARS-CoV-2 variants. The EC50 for SARS-CoV-2 and HCoV-229E are 0.62 μM and 0.14 μM. BPR3P0128 demonstrates effective anti-pancoronavirus activity within the submicromolar range. PR3P0128 shows synergistic antiviral activity when combined with Remdesivir (HY-104077)[1].
[in vivo]


Pharmacokinetic Analysis in Sprague-Dawley rats Model[1]

RouteDose (mg/kg)Cl (mL min/kg)t1/2 (h)F (%)
i.v.0.011.3//
p.o.0.01/8.178.7%
[References]

[1] Tang W-F, et al. BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir. Antimicrob Agents Chemother. 2024;68(4):e0095623. DOI:10.1128/aac.00956-23
[2] Yeh JY, et al. Anti-influenza drug discovery: identification of an orally bioavailable quinoline derivative through activity- and property-guided lead optimization. ChemMedChem. 2012;7(9):1546-1550. DOI:10.1002/cmdc.201200259
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