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ChemicalBook--->CAS DataBase List--->134186-26-8

134186-26-8

134186-26-8 Structure

134186-26-8 Structure
IdentificationBack Directory
[Name]

KF 14124
[CAS]

134186-26-8
[Synonyms]

KF 14124
Dptpp-2-ismn
[Molecular Formula]

C19H27N3O5S
[MOL File]

134186-26-8.mol
[Molecular Weight]

409.5
Chemical PropertiesBack Directory
[Boiling point ]

556.3±50.0 °C(Predicted)
[density ]

1.33±0.1 g/cm3(Predicted)
[pka]

7.55±0.10(Predicted)
Hazard InformationBack Directory
[Description]

KF 14124 showed potent anti-ischemic activity in a lysine-vasopressin-induced angina pectoris model (rats).
[Uses]

KF-14124, an orally active organic nitrate, a long-acting vasodilator with highly selective venous dilating action. KF-14124 is used in the study for angina pectoris. KF-14124 shows good oral inhibition of lysine-vasopressin induced coronary vasospasm with a potency[1][2].
[in vivo]

KF-14124 (0.3 mg/kg intraduodenal administration (i.d.)) tends to decrease left ventricular end-diastolic pressure (LVEDP) in a Propranolol-induced heart failure model (dogs) and shows a potent protective effect against reperfusion arrhythmia in rats[1].

[References]

[1] 1,4:3,6-Dianhydrohexitol nitrate derivatives. I. Synthesis and antianginal activity of alkylpiperazine derivatives. Chem Pharm Bull (Tokyo). 1993 Jun;41(6):1091-9. DOI:10.1248/cpb.41.1091
[2] Giorgio Bertolini, et al. Overview: Recent Advances in Organic Nitrates. Current Opinion on Therapeutic Patents Volume 3, 1993 - Issue 10.
134186-26-8 suppliers list
Company Name: TargetMol Chemicals Inc.
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Website: https://www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website:
Company Name: TargetMol Chemicals Inc.  
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Website: https://www.targetmol.cn/
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