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KF 14124 showed potent anti-ischemic activity in a lysine-vasopressin-induced angina pectoris model (rats). | [Uses]
KF-14124, an orally active organic nitrate, a long-acting vasodilator with highly selective venous dilating action. KF-14124 is used in the study for angina pectoris. KF-14124 shows good oral inhibition of lysine-vasopressin induced coronary vasospasm with a potency[1][2]. | [in vivo]
KF-14124 (0.3 mg/kg intraduodenal administration (i.d.)) tends to decrease left ventricular end-diastolic pressure (LVEDP) in a Propranolol-induced heart failure model (dogs) and shows a potent protective effect against reperfusion arrhythmia in rats[1]. | [References]
[1] 1,4:3,6-Dianhydrohexitol nitrate derivatives. I. Synthesis and antianginal activity of alkylpiperazine derivatives. Chem Pharm Bull (Tokyo). 1993 Jun;41(6):1091-9. DOI:10.1248/cpb.41.1091 [2] Giorgio Bertolini, et al. Overview: Recent Advances in Organic Nitrates. Current Opinion on Therapeutic Patents Volume 3, 1993 - Issue 10. |
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