| Identification | Back Directory | [Name]
Hydroxy-PEG3-t-butylester | [CAS]
133803-81-3 | [Synonyms]
OH-PEG2-TBA
HO-PEG2-COOtBu
HO-PEG2-CH2CH2COOtBu
OH-PEG2-CH2CH2COOtBu
HO-PEG2-t-Butyl ester
Hydroxy-PEG2-(CH2)2-Boc
Hydroxy-PEG3-t-butylester
Hydroxy-PEG2-t-butyl ester
tert-Butyl PEG2 propanoate
PEG3-carboxylic Acid tert-Butyl Ester
tert-Butyl 9-Hydroxy-4,7-dioxanonanoate
9-Hydroxy-4,7-dioxanonanoic Acid tert-Butyl Ester
TERT-BUTYL 3-(2-(2-HYDROXYETHOXY)ETHOXY)PROPANOATE
3-[2-(2-Hydroxyethoxy)ethoxy]propanoic Acid tert-Butyl Ester
Propanoic acid, 3-[2-(2-hydroxyethoxy)ethoxy]-, 1,1-dimethylethyl ester | [Molecular Formula]
C11H22O5 | [MDL Number]
MFCD20926380 | [MOL File]
133803-81-3.mol | [Molecular Weight]
234.29 |
| Chemical Properties | Back Directory | [Boiling point ]
321.8±22.0 °C(Predicted) | [density ]
1.046±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Soluble in DMSO | [form ]
clear liquid | [pka]
14.36±0.10(Predicted) | [color ]
Colorless to Almost colorless |
| Hazard Information | Back Directory | [Description]
Hydroxy-PEG2-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Hydroxy-PEG2-(CH2)2-Boc is an ADC linker for the synthesis of antibody drug conjugates (ADC), Hydroxy-PEG2-(CH2)2-Boc is derived from patent WO2004008101A2 (compound 196). Hydroxy-PEG2-(CH2)2-Boc can also be used as a PROTAC linker for PROTAC synthesis. | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [IC 50]
Non-cleavable Linker; PEGs; Alkyl/ether |
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