| Identification | Back Directory | [Name]
t-Boc-N-Amido-PEG3-propargyl | [Synonyms]
Propargyl-PEG3-NHBoc
Boc-NH-PEG3-propargyl
Boc-N-Amido-PEG3-Alkyne
t-Boc-N-Amido-PEG3-propargyl
5,8,11-Trioxa-2-azatetradec-13-ynoic acid, 1,?1-?dimethylethyl ester
tert-Butyl (2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)carbamate | [MDL Number]
MFCD30534430 | [MOL File]
1333880-60-6.mol |
| Hazard Information | Back Directory | [Description]
t-Boc-N-Amido-PEG3-propargyl enables formation of triazole linkage with azide-bearing compound via copper catalyzed Click Chemistry. Under mild acidic conditions, t-Boc group can be removed to yield the free amine. | [Uses]
Boc-NH-PEG3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG3-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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