| Identification | Back Directory | [Name]
Debio 0617B | [CAS]
1332329-27-7 | [Synonyms]
Debio 0617B
DEBIO0617B;DEBIO-0617B
4-trifluoromethyl-pyridine-2-carboxylic acid {4-chloro-3-[2-(4-methylcarbamoyl-phenylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-phenyl}-amide
2-Pyridinecarboxamide, N-[4-chloro-3-[7,8-dihydro-2-[[4-[(methylamino)carbonyl]phenyl]amino]pyrido[4,3-d]pyrimidin-6(5H)-yl]phenyl]-4-(trifluoromethyl)- | [Molecular Formula]
C28H23ClF3N7O2 | [MDL Number]
MFCD30749186 | [MOL File]
1332329-27-7.mol | [Molecular Weight]
581.98 |
| Hazard Information | Back Directory | [Uses]
Debio 0617B, a multi-kinase inhibitor, reduces maintenance and self-renewal of primary human AML CD34+?stem/progenitor cells. Debio 0617B has a unique profile targeting key kinases upstream of STAT3/STAT5 signaling such as JAK, SRC, ABL, and class III/V receptor tyrosine kinases (TKs). Debio 0617B has documented efficacy in STAT3-driven solid tumors[1]. | [References]
[1] Maximilien Murone,?et al. The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34+?Stem/Progenitor Cells. Mol Cancer Ther.?2017 Aug;16(8):1497-1510. DOI:10.1158/1535-7163.MCT-16-0889 |
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| Company Name: |
ABBIOCHEM
|
| Tel: |
021-18964309092 18964309092 |
| Website: |
www.abbiochemical.com |
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