| Identification | Back Directory | [Name]
3PO | [CAS]
13309-08-5 | [Synonyms]
(E)3PO,(E) 3PO
3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
2-Propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)- | [Molecular Formula]
C13H10N2O | [MOL File]
13309-08-5.mol | [Molecular Weight]
210.23 |
| Chemical Properties | Back Directory | [Melting point ]
144-147°C | [Boiling point ]
387.8±42.0 °C(Predicted) | [density ]
1.192±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
4.20±0.12(Predicted) | [color ]
Pale Yellow to Yellow |
| Hazard Information | Back Directory | [Uses]
3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one inhibits human bladder cancer cell lines growth. It also inhibits cancer cell growth proliferation by it’s treatment in combination with phenoformin. An inhibitor of 6-phosphofructo-2- kinaselfructose-2,6-bisphosphatase 3 (PFKFB). | [Definition]
ChEBI: 3PO is a member of the class of pyridines that is pyridine substituted by a 3-oxo-3-(pyridin-4-yl)prop-1-en-1-yl group at position 3. An inhibitor of PFKFB3 kinase, an enzyme with a key role in glycolysis. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an autophagy inducer, an apoptosis inducer and an EC 2.7.1.105 (6-phosphofructo-2-kinase) inhibitor. It is a member of pyridines and an enone. | [storage]
Store at -20°C |
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