| Identification | Back Directory | [Name]
MAT2A inhibitor 1 | [CAS]
13299-99-5 | [Synonyms]
AG270
AG-270
AG 270
MAT2A inhibitor 1
AG-270(MAT2A inhibitor 1)
AG-270;AG270;AG 270;13299-99-5
6-(3-Methoxyphenyl)-4-methyl-2-(2-morpholinoethyl)pyridazin-3(2H)-one hydrochloride
6-(3-methoxyphenyl)-4-methyl-2-(2-morpholin-4-ylethyl)pyridazin-3-one,hydrochloride | [Molecular Formula]
C18H24ClN3O3 | [MOL File]
13299-99-5.mol | [Molecular Weight]
365.86 |
| Chemical Properties | Back Directory | [Melting point ]
203-209 °C | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMSO : 75 mg/mL (205.00 mM) | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MAT2A inhibitor 2 is an inhibitor of methionine adenosine transferase 2A (MAT2A) with oral activity. MAT2A inhibitor 2 can be used in osteoporosis study[1] | [in vivo]
MAT2A inhibitor 2 (30, 100 mg/kg, orally, for 6 weeks) can prevent bone loss induced by ovariectomy (OVX) in mice[1].
| Animal Model: | Ovariectomy (OVX)-induced osteoporosis model in C57/BL mice[1] | | Dosage: | 30, 100 mg/kg | | Administration: | p.o. for 6 weeks | | Result: | Attenuated trabecular thickness and osteoclast surface/bone surface ratio (Oc.S/BS). |
| [storage]
Store at -20°C | [References]
[1] Kang H, et al. Inhibition of MAT2A suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss. FASEB J. 2022 Feb;36(2):e22167. DOI:10.1096/fj.202101205RR |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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