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ChemicalBook--->CAS DataBase List--->132699-73-1

132699-73-1

132699-73-1 Structure

132699-73-1 Structure
IdentificationBack Directory
[Name]

(LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT)
[CAS]

132699-73-1
[Synonyms]

[LEU31,PRO34] NPY, HUMAN
(LEU31,PRO34)-NPY (HUMAN, RAT)
M.W. 4240.67 C189H284N54O56S
[LEU31,PRO34] NEUROPEPTIDE Y, HUMAN
YPSKPDNPGEDAPAEDMARYYSALRHYINLLTRPRY-NH2
(LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT)
TYR-PRO-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-LEU-THR-ARG-PRO-ARG-TYR-NH2
H-TYR-PRO-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-LEU-THR-ARG-PRO-ARG-TYR-NH2
TYR-PRO-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-LEU-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-LEU-THR-ARG-PRO-ARG-TYR-NH2: YPSKPDNPGEDAPAEDLARYYSALRHYINLLTRPRY-NH2
[Molecular Formula]

C189H284N54O56S
[MDL Number]

MFCD00132605
[MOL File]

132699-73-1.mol
[Molecular Weight]

4240.67
Chemical PropertiesBack Directory
[storage temp. ]

−20°C
[solubility ]

Soluble in DMSO
[form ]

Powder
[Water Solubility ]

Soluble to 1 mg/ml in water
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

[Leu31,Pro34]-Neuropeptide Y(human,rat) is a specific neuropeptide Y Y1 receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) slao activates Y4, Y5. [Leu31,Pro34]-Neuropeptide Y(human,rat) can increase blood pressure in anesthetized rats and increases food intake[1][2].
[in vivo]

[Leu31,Pro34]-Neuropeptide Y(human,rat) (30 pmol; microinjected into paraventricular nucleus) increases food intake in the rats (350±400 g)[3].

[IC 50]

NPY Y1 receptor; NPY Y4 receptor; NPY Y5 receptor
[storage]

Store at -20°C
[References]

[1] J Fuhlendorff, et al. [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist. Proc Natl Acad Sci U S A. 1990 Jan;87(1):182-6. DOI:10.1073/pnas.87.1.182
[2] K McCrea, et al. 2-36[K4,RYYSA(19-23)]PP a novel Y5-receptor preferring ligand with strong stimulatory effect on food intake. Regul Pept. 2000 Feb 8;87(1-3):47-58. DOI:10.1016/s0167-0115(99)00108-1
[3] A Kask, et al. Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226. Br J Pharmacol. 1998 Aug;124(7):1507-15. DOI:10.1038/sj.bjp.0701969
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