| Identification | Back Directory | [Name]
Methyl 4-bromo-2-chloro-6-fluorobenzoate | [CAS]
1321613-02-8 | [Synonyms]
Methyl 4-bromo-2-chloro-6-fluorobenzoate
4-bromo-2-chloro-6-fluorobenzoic acid methyl ester
Benzoic acid, 4-bromo-2-chloro-6-fluoro-, methyl ester | [Molecular Formula]
C8H5BrClFO2 | [MDL Number]
MFCD22574196 | [MOL File]
1321613-02-8.mol | [Molecular Weight]
267.48 |
| Chemical Properties | Back Directory | [Boiling point ]
299.4±40.0 °C(Predicted) | [density ]
1.675±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [Appearance]
Colorless to light yellow Liquid |
| Hazard Information | Back Directory | [Synthesis]
Procedure for the synthesis of methyl 4-bromo-2-chloro-6-fluorobenzoate: to a mixture of compound 4-bromo-2-chloro-6-fluorobenzoic acid (20 g, 80 mmol) and potassium carbonate (13.2 g, 96 mmol) in N,N-dimethylformamide (200 mL) was added methylene iodide (23 g, 160 mmol). The reaction mixture was stirred at room temperature for 2 hours and subsequently poured into water (600 mL) and extracted with dichloromethane (2 x 200 mL). The organic layers were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a brown oil. Purification by silica gel column chromatography (petroleum ether: ethyl acetate = 100:1) gave the target product methyl 4-bromo-2-chloro-6-fluorobenzoate (8 g, 49% yield, two-step reaction) as a light yellow oil. | [References]
[1] Patent: US2012/28952, 2012, A1. Location in patent: Page/Page column 17 |
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