| Identification | Back Directory | [Name]
AT 1001 | [CAS]
1314801-63-2 | [Synonyms]
AT 1001
9-Azabicyclo[3.3.1]nonan-3-amine, N-(2-bromophenyl)-9-methyl-, (3-endo)- | [Molecular Formula]
C15H21BrN2 | [MOL File]
1314801-63-2.mol | [Molecular Weight]
309.25 |
| Chemical Properties | Back Directory | [Boiling point ]
395.6±37.0 °C(Predicted) | [density ]
1.327±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.96±0.40(Predicted) | [color ]
Brown to dark brown |
| Hazard Information | Back Directory | [Description]
AT-1001 is a novel potent and selective partial agonist of human and rat α3β4 nicotinic cholinergic receptors. | [Uses]
AT 1001 is a high-affinity and selective antagonist of the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR) (Ki=2.64 nM). AT 1001 reversibly blocks inward currents induced by Epibatidine (HY-101078) in HEK cells transfected with α3β4 nAChR. AT-1001 dose-dependently inhibits nicotine self-administration behavior in rats without affecting food-reinforced responding. AT 1001 can be utilized in the research of nicotine addiction and smoking cessation therapies[1]. | [References]
[1] Toll L, et al. AT-1001: a high affinity and selective α3β4 nicotinic acetylcholine receptor antagonist blocks nicotine self-administration in rats[J]. Neuropsychopharmacology, 2012, 37(6): 1367-1376. DOI:10.1038/npp.2011.322 |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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